One-Pot Three-Component Synthesis of 2-Amino-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile Derivatives Catalyzed by Cobalt Doped Iron (III) Tartrate Complex

Abstract

An environmentally friendly one-pot three-component strategy synthesizing a series of 2-Amino-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives has been successfully performed in water. The products were obtained through conventional and microwave irradiation, which involving aldehyde, malononitrile, and 4-hydroxy coumarin, resulting in a green synthetic protocol with a high atom economy. The reaction was catalyzed by a water-soluble and reusable catalyst, i.e., cobalt doped iron (III) tartrate complex. The catalyst was recovered and efficiently reused.