Abstract
The breakdown products of 5 dinucleotides, several trinucleotides and the pentanucleotide hU-hU-A-A-Gp after digestion with varying amounts of ribonuclease U 2 have been analyzed. The data show the following specificities of the enzymatic attack. A-X > G-X, Pu-C > Pu-U, terminal bonds are cleaved more readily than internal bonds, and substrates carrying 2′,3′ cyclic phosphate end groups are much more resistant than those carrying an open phosphate group. Certain pyrimidine bonds such as in hU-hU-A are also attacked.
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