Observation on the total bile acid in the blood serum in neonatal hyperbilirubinemia

Abstract

Objective To investigate the change of the bile acid in the blood serum and its significance in the neonates with hyperbilirubinemia.Methods The levels of total bile acid (TBA),the cytomegalovirus IGM and the liver function including the AST,the ALT and the GGT were detected in 298 neonates with hyperbilirubinemia.The neonates were divided into two groups by the levels of total bilirubin in the blood serum the light-degree and severedegree group,and which need to compare with the control group consisting of 29 neonates.Results There were 254neonates in the light-degree group and 44 in the severe-degree group.Making comparison of the average value including AST,ALT,GGT,TBA and the positive rate,it showed that there was no statistical significance between the two groups (P ＞ 0.05).The GGT and TBA in both the light-and severe-degree group were higher than the control group,the difference had statistical significance(P ＜0.01).Testing the CMV-IgM of 214 neonates with hyperbilirubinemia,it showed that the results were all normal.Conclusion Most neonates with hyperbilirubinemia suffer from liver parenchyma injury and cholestasis,also the levels of TBA in the blood serum have no concern with the degree of jaundice.So the liver protection drugs can be properly used in the treatment.The TBA is more sensitive than the ALT to diagnose the liver parenchyma injury in neonates with hyperbilirubinemia. Key words: Hyperbilirubinemia ; Total bile acid; Infant, newborn