Changes of serum total bile acid and cholesterol in perimenopausal patients with coronary heart disease and their relationship

Abstract

Objective To investigate the changes of serum total bile acid levels and cholesterol levels in perimenopausal patients with coronary heart disease and their relationship. Methods A total of 240 perimenopausal patients who underwent coronary angiography in the First Affiliated Hospital of Zhengzhou University from July 2017 to September 2018 were randomly selected. Those patients were divided into coronary heart disease group (n=135) and non-coronary heart disease group (control group, n=105) according to the results of coronary angiography. The total serum cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total serum bile acids levels of the two groups were observed and the differences between those data was studied. The relationship between total bile acids and coronary heart disease and its correlation with cholesterol was analyzed. Results The levels of total cholesterol, low-density lipoprotein cholesterol and total bile acid in the coronary heart disease group were significantly higher than those in the control group (P all <0.05). Logistic regression analysis showed that diabetes, total cholesterol, and total bile acid were independent risk factors for perimenopausal patients with coronary heart disease, the OR values were 4.061, 1.984 and 1.125 respectively, and the correlation analysis showed significant positive correlation of total bile acid levels with total cholesterol levels (r=0.799, P<0.05). Conclusions Total bile acid level is closely related to the occurrence of coronary heart disease and total cholesterol metabolism in perimenopausal patients. Key words: Perimenopausal; Coronary heart disease; Total bile acid; Cholesterol