Observation on the influence of laparoscopic operation for the postoperative body stress and inflammatory state of patients with gastric and duodenal ulcer perforation

Abstract

Objective To observe and investigate the influence degree of laparoscopic operation for the postoperative body stress and inflammatory state of patients with gastric and duodenal ulcer perforation. Methods 76 patients with gastric and duodenal ulcer perforation were selected as study subjects, and they were divided into control group(conventional open operation group) and observation group(laparoscopic operation group) according to the random number table, 38 cases in each group.The serum body stress hormones and antiinflammatory, proinflammatory related indexes of the two groups at first day before operation and at first, third, seventh day after operation were respectively detected and compared. Results The serum IL-2 levels of the observation group at first, third and seventh day after operation were (3.53±0.24)μg/mL, (3.25±0.22)μg/mL and (4.37±0.33)μg/mL, which were higher than those of the control group(F=5.876, P<0.05), while other serum body stress hormones and antiinflammatory, proinflammatory related indexes were all obviously lower than those of the control group (all P<0.05), there were significant differences between those postoperative evaluation results of the two groups. Conclusion The influence of laparoscopic operation for the postoperative body stress and inflammatory state of patients with gastric and duodenal ulcer perforation is relatively small, and it shows that the bad body stress degree caused by the operation is relatively smaller. Key words: Laparoscopic operation; Peptic ulcer perforation; Stress