Observation of the effect of neoadjuvant chemotherapy for patients with advanced cervical cancer

Abstract

Objective To observe the effect of neoadjuvant chemotherapy for patients with advanced cervical cancer.Methods According to the digital table ,106 patients with advanced cervical cancer were randomly divided into the two groups ,53 cases in each group .The observation group was given TP Scheme neoadjuvant chemotherapy before surgery ,the control group underwent surgery directly .The total effective rate of chemotherapy and the changes of diameter of tumor before and after chemotherapy were observed .The serum levels of vascular endothelial growth fac-tor（VEGF） and matrix metalloproteinase-9（MMP-9） of the observation group were detected ,and the operation condi-tions were compared between the two groups .Results After chemotherapy ,the total effective rate of the observation group was 60.4%.Before and after chemotherapy ,the average tumor diameter of the observation group was （5.24 ± 1.35）cm,（2.64 ±0.67）cm,respectively,the difference was significant （t=3.947,P〈0.05）.The operative time, blood loss and lymph node metastasis in the observation group were significantly less than those in the control group （t=3.725,5.392,χ2 =4.28,P〈0.05 or P〈0.01）.After chemotherapy,the serum levels of VEGF and MMP-9 were significantly lower than that before chemotherapy （t=3.130,4.724,all P〈0.05）.Conclusion Neoadjuvant chemotherapy in the treatment of advanced cervical cancer can significantly reduce serum VEGF and MMP-9 expression. Key words: Uterine cervical neoplasms; Antineoplastic combined chemotherapy protocols; Vascular endothe-lial growth factors; Matrix metalloproteinase 9