DeFazio capsules oxaliplatin neoadjuvant chemotherapy on matrix metalloproteinase-9 and vascular endothe-lial growth factor in patients with advanced gastric cancer

Abstract

Objective To study DeFazio capsules oxaliplatin neoadjuvant chemotherapy on matrix metallo-proteinase-9 （ MMP-9 ） and vascular endothelial growth factor （ VEGF ） in patients with advanced gastric cancer . Methods 92 patients with advanced gastric cancer were randomly divided into the two groups ,the observation group （ n=46 ） and the control group （ n=46 ） .Both two groups were used neoadjuvant chemotherapy , DeFazio capsules oxaliplatin chemotherapy for the observation group and capecitabine oxaliplatin chemotherapy for the control group . Expression of MMP-9 and VEGF was determined by immunohistochemistry in gastric cancer tissues .Results After chemotherapy,the total effective rate was 60.9%in the control group and 80.4%in the observation group.The total effective rate of the observation group was significantly higher （χ2 =6.42,P〈0.05）.The anemia,thrombocyto-penia,hepatic dysfunction ,renal dysfunction ,the incidence of nausea and vomiting had no significant differences be-tween the two groups （χ2 =1.52,0.96,2.06,0.00,1.28,all P〉0.05）.Neutropenia,neurotoxicity in the observation group were less than the control group （χ2 =5.68,4.18,all P〈0.05）.Before chemotherapy,the positive rates of VEGF and MMP-9 expression in the control group were 93.5%,78.3%.Those of the observation group were 89.1%and 82.6%,respectively,the differences were not significant （χ2 =2.12,2,72,all P〉0.05）.After the chemothera-py,the positive expression rates of VEGF and MMP-9 in the control group were 45.7%,41.3%,respectively.Those of the observation group were 23.9%and 21.7%,respectively.VEGF and MMP-9 positive expression rates were sig-nificantly lower than before chemotherapy （χ2 =4.72,4.08,10.14,9.84,P〈0.05,P〈0.01）.The observation group was significantly lower than the control group （χ2 =5.14,4.72,all P〈0.05）.Conclusion DeFazio capsules oxali-platin neoadjuvant chemotherapy can decrease MMP-9 and VEGF expression in patients with advanced gastric cancer . Key words: Stomach neoplasms ; Chemoradiotherapy, adjuvant ; Matrix metalloproteinase 9 ; Vascular endothe-lial growth factors