Abstract
The antimicrobial activity of tissue engineering scaffolds is crucial for successful implantations and surgeries by reducing surgical infections. In this study, small intestinal submucosa (SIS) extracts were prepared by in vitro pepsin digestion (pSIS) and its antimicrobial active is stronger than those prepared by accelerated hydrolysis (aSIS). Compared with aSIS, the average molecular weight of pSIS seems smaller with more narrow distribution via SDS-PAGE electrophoresis combined with commassie blue staining. Furthermore, pSIS coated porous type I collagen scaffold (pSIS/COL I scaffolds) displayed a strong antibacterial activity and is suitable for cell seeded and growth, indicating that it can be potentially applied to tissue engineering or surgical tissue repairing in the future.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: IOP Conference Series: Materials Science and Engineering
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
