Abstract
Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology and neuroinflammation research, and coverage extending to other basic and clinical studies related to neuroscience.
Highlights
The most prevalent neurodegenerative disorder that has dramatically increased over the last 60 years is Alzheimer’s disease (AD)
A significant decrease in neuronal cell death and a significant decline in F2-Isoprostane levels were observed in rats treated with edible bird’s nest (EBN)
This is the first study to associate the neuroprotective effect of EBN in the prevention of dementia related to AD
Summary
The most prevalent neurodegenerative disorder that has dramatically increased over the last 60 years is Alzheimer’s disease (AD). AD is a chronic disorder that starts years before the detection of any clinical cognitive decline, with memory loss and a decline in cerebral blood supply[1,2,3]. A continuous decrease in regional cerebral blood flow (CBF) in different areas in the rat brain including the cerebral cortex and hippocampus causes neuronal dysfunction and impairs spatial learning, leading to memory deficits and dementia[3,7,9]. Previous studies of neuropathological changes caused by CCH focused on the hippocampus due to its essential role in learning and memory[8,10,11,12]. In order to diagnose and treat the pathophysiological changes of CCH in an animal model, the detection of essential biomarkers would have a critical role. IsoPs are considered an accurate predictor of lipid peroxidation due to their biological stability[13,14,15,16]
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