Abstract
Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology and neuroinflammation research, and coverage extending to other basic and clinical studies related to neuroscience.
Highlights
Microglia have a finely tuned array of receptors that enable them to discriminate incoming homeostatic, damage and pathogenic signals and respond appropriately
We review the current knowledge of Alzheimer’s disease (AD) risk genes and the variants impacting their function
Review of genes associated with Alzheimer’s Disease We have reviewed gene wide association studies (GWAS), exome and whole genome sequencing studies and present a list of 84 genes which have been reliably associated with AD in independent and well-powered studies [Table 1]
Summary
Microglia have a finely tuned array of receptors that enable them to discriminate incoming homeostatic, damage and pathogenic signals and respond appropriately. Whilst knowledge of these risk variants in these genes may never be useful by themselves for establishing individual clinical diagnosis, they have considerable value in refining pathways of vulnerability which can be targeted for therapeutic development, for identifying and enriching high risk participants for clinical trials related to these pathways and supporting diagnosis as part of a panel of factors including clinical and biomarker assessments as part of a composite risk score. Family- AD based + GWAS WES AD (familial) WES AD+ (familial) NDother GWAS AD rs184384746 [gene-wise] [gene-wise] rs6448453 rs137875858
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