Abstract
Nerve Regeneration in Vein Grafts Seeded with Adult Schwann Cells
Highlights
In cases where a nerve is cut, a nerve graft sometimes maybe essential in the gap between the proximal and the distal part of a nerve
Namely polyglycolic acid (PGA), polylactic acid or polylactide (PLA), polylactic-coglycolic acid (PLGA) and polyhydroxyalkanoate (PHA) are usually useful when general and specific situations limit the use of natural grafts [1,2,3,4]
To better decipher the role Schwann cells play in nerve regeneration, it was discovered that Schwann cells change the naked peripheral axons into myelinated fibers via folding several times around them to make myelin while Schwann cells only surround fine axons to cover them without myelinating them
Summary
In cases where a nerve is cut, a nerve graft sometimes maybe essential in the gap between the proximal and the distal part of a nerve. Bungner’s bands provide leading bridges to help axons reach the distal side of the damaged area where there is a gap to shorten the trip from the proximal to the distal [1,5] ends. This is the cornerstone of axonal regrowth and nerve repair since the distal part of the damage would decay and regeneration can only be accomplished by the only living side. Since endogenous Schwann cells are not sufficient, exogenously cultured cells play an essential role in axonal regeneration, especially in peripheral locations
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