MIF Promotes Bone Defect Repair by Regulating Macrophages

Jian Li ,Cheng Pz ,J Wang ,Wu H ,Li D ,Longlong Yang ,Zhang Ss ,Pan Ds ,Gao Yj ,Huiping Jiang ,Guangsheng Pei

doi:10.16966/2472-6990.119

Abstract

MIF Promotes Bone Defect Repair by Regulating Macrophages

Highlights

Bone defect, caused by trauma, resection of bone tumor, osteomyelitis and congenital bone defect, causes great pain to the patients physically and psychologically
It is of great significance to study the specific mechanism of bone defect healing so as to take targeted measures to promote fracture healing
Especially macrophages, can be detected immediately in the early stages of bone injury [11]. These macrophages induce a cascade of reactions that first remove the blood clots forming after injury and lead the m to be replaced by granulation tissues [12]; followed by the initiation of anabolism of granulation tissue, inducing its gradual evolvement into periosteal callus tissue or bone bridge available for the structure; these temporary bones structures were gradually remodeled with normal bone structure and strength [13]

Summary

Introduction

Bone defect, caused by trauma, resection of bone tumor, osteomyelitis and congenital bone defect, causes great pain to the patients physically and psychologically. It is of great significance to study the specific mechanism of bone defect healing so as to take targeted measures to promote fracture healing. Macrophage is an indispensable factor in the process of bone repair. Et al [1] found that the mice bone could not be repaired with the macrophages being cleared. Macrophages promote bone repair by inducing bone formation and regulating bone resorption [2]. The factors regulate macrophages in bone repair is still unknown. Considering the robust effect of MIF on macrophages, this study aim to observe whether MIF can promote bone repair by regulating macrophages

Methods

Results

Conclusion