Abstract
Facultative anaerobiosis occurs widely across phylogeny and comparative studies with multiple animal models are identifying conserved molecular mechanisms that support anoxia tolerance. Our studies of freshwater turtles have analyzed metabolic, signal transduction and gene expression responses to anoxia. A key mechanism is reversible protein phosphorylation, which provides coordinate suppression of the rates of ATP-producing versus ATP-utilizing cellular processes to achieve strong metabolic rate depression (MRD). Anoxia tolerance is also supported by selective gene expression as revealed by cDNA library and cDNA array screening. Prominent groups of genes that are up-regulated under anoxia in turtle organs include mitochondrially encoded subunits of electron transport chain proteins and several serine protease inhibitors.
Published Version
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