Abstract
The Gray Mouse Lemur: A Model for Studies of Primate Metabolic Rate Depression
Highlights
Peer review under responsibility of Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China
We have identified conserved metabolic mechanisms that are used across the animal kingdom to coordinate and regulate metabolic rate depression, reprioritize ATP expenditures to conserve energy, stabilize macromolecules, and maximally extend viability in the hypometabolic state
In the group of papers that follows, we put our toolkit of metabolic markers and our multiplex assay methods to use for a broad-based and comprehensive analysis of the biochemical responses to daily torpor in six organs of gray mouse
Summary
Much information about the molecular, biochemical and physiological mechanisms of natural hibernation has been derived from these studies [1,2,3,4], there are some questions about the applicability of this work to development of inducible torpor in humans. For example: (1) would the genes, proteins, and molecular mechanisms involved in torpor/ hibernation in rodents apply to humans?
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