Abstract
Background: Many observational studies suggest a possible benefit of metformin in treatment of severe coronavirus disease 2019 (Covid-19), but evidence from randomized trials is limited. Objective: To evaluate the therapeutic role of metformin in Covid-19 based on randomized trials. Methods: PubMed review until May 12, 2023. Key words are Covid-19, metformin, long Covid, mortality. Randomized trials, retrospective studies, pre-print articles, and meta-analyses are included.
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