Abstract
Electrochemical biosensors (EBS) have recently gained much attention in the field of health care for the management of cholesterol (CHO). This review comprises a report on the modification of electrode surfaces with metal nanoparticles (MNP) for selective and sensitive sensing of CHO. Quantitative analysis of cholesterol is carried out with the use of the amperometric data of linear calibration plot. A good synergistic between MNP of working electrode (WE) and CHO give fast electron transfer and precised electrochemical detection of CHL.
Highlights
Monitoring of CHO in blood is very important to control health issues related to its abnormal levels
In the fabrication of Electrochemical biosensors (EBS), cholesterol oxidase (ChOx) is most commonly used as the biosensing element that remain immobilized with different type of electroactive materials
Due to high conducting properties of metal nanoparticles (MNP) with different binders, they have been effectively immobilized with ChOx and used for surface modification of working electrode (WE) to sense CHO
Summary
Monitoring of CHO in blood is very important to control health issues related to its abnormal levels. Electrochemical methods has received immense acceptance selectivity for CHL sensing, because of reasonable simplicity, low cost, a wide working range and high sensitivity. It is required to focus on the chemical modifications of WE surface to improve its selective sensing for a target molecule. In the fabrication of EBS, cholesterol oxidase (ChOx) is most commonly used as the biosensing element that remain immobilized with different type of electroactive materials. Due to high conducting properties of MNP with different binders, they have been effectively immobilized with ChOx and used for surface modification of WE to sense CHO. The EBS efficiency mainly depends on the modification of working electrode surface with different electro active coating materials. In the present review we compiled various types of MNP based EBS for trace level CHO estimation
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