Abstract
Background: Exercise and dietary modifications help improve energy balance and glucose control. High intensity interval exercise (HIIE) induces an increase in serum brain-derived neurotrophic factor (BDNF) with a corresponding decrease in its precursor (proBDNF). Pro-BDNF, possesses biological activities opposite those of BDNF. However, only few reports on the effect of HIIE on proBDNF compared to extensive studies on the BDNF.
 Methods: Normal, healthy, male adults performed six sessions of HIIE in a span of 2 weeks. Venous blood was collected, from which fasting blood sugar, glycated haemoglobin, serum insulin, BDNF and proBDNF were measured using ELISA. 
 Results: Marked decrease in markers of glycemic control were recorded following the intervention. A reduction in proBDNF and increase in BDNF was also observed post exercise. We found a strong negative relationship between BDNF and FBS post exercise. 
 Conclusion: HIIE reduces BDNF and proBDNF healthy men.
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