Abstract
The coronavirus disease 2019 (COVID-19) outbreak, prompted by SARS-CoV-2, has had far-reaching global consequences, needing a multidimensional response including public health, economic, and scientific endeavours. Although vaccinations have been produced, new mutations pose difficulties. Genetics of the host has been identified as a crucial determinant of COVID-19 illness severity, with studies finding particular genetic variants associated with disease manifestations. However, there is a lack of studies on genetic risks in the Association of Southeast Asian Nations (ASEAN) region. This review seeks to fill this void by investigating the genetic risks of COVID-19 across ASEAN countries, considering the region’s different populations, demographics, and social factors. We review recent research on genetic variations linked to COVID-19 susceptibility, severity, and viral burden from Thailand, Indonesia, and Vietnam. These findings are consistent with global reports emphasising the significance of TMPRSS2, ACE2, IFNAR2, and TYK2 genes. However, additional study is required to clarify genetic variables across all ASEAN nations. It is critical to address problems such as limited sample numbers, study design, and replication of findings to confirm these correlations. Furthermore, considering demographic, socioeconomic, and cultural characteristics influencing COVID-19 outcomes among ASEAN countries is critical for effective public health interventions. To better combat the pandemic, the ASEAN area must address these obstacles and increase its research efforts to gain a more in-depth understanding of the genetic risks associated with COVID-19 within the region’s various ASEAN populations.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call