Literature metrology analysis of adverse reaction reports of Reduning injection

Abstract

Objective To investigate the general rules and features of drug adverse reaction induced by Reduning injection inorder to provide reference for clinical rational administration. Methods The literatures about the advers reaction induced by Reduning injection published from 2008-2014 in China were retrieved.The articles were analysed using literature metrology methods. Results 25 articles related to 282 individual cases were retrieved.The adverse reactions were related to sexuality and drug combination.Children were the high risk group.Incidence rate of the adverse reaction of boys was much higher than that of girls.Combination with antibacterials might increase the incidence rate of adverse reaction.The major clincal manifestation was the adverse reaction of dermal system(208 case)and anaphylactic response(36 case).Anaphylactic shock was the serious reaction in clinical(11 case). Conclusion Clinician and pharmacists should understand the rules and characteristic of adverse reaction caused by reduning injection.Using drug must according to the direction in clinical.It must pay more attention to medication monitoring in order to reduce the occurrence of drug adverse reaction. Key words: Reduning injection; Adverse reaction; Literature analysis