Lienal polypeptide combined with CO2 laser in treatment of condyloma acuminatum

Abstract

Objective To investigate the clinical efficacy of lienal polypeptide combined with CO2 laser in the treatment of condyloma acuminatum and the influence on cellular immune. Methods 144 patients with condyloma acuminatum were included, and randomly divided into an observation group and a control group, 72 cases for each group. The control group were treated with CO2 laser, while the observation group with intramuscular lienal polypeptide and CO2 laser. The clinical efficacies and the differences in the distribution of T lymphocyte subgroups in peripheral blood were compared between the two groups. Meanwhile, 50 healthy people were chosen as a normal group. Results The cured rate and the recurrence rate were 79.2% and 20.8% in the observation group, and were 55.6% and 44.4% in the control group, respectively, with statistical differences (χ2=9.128 and 4.267, P=0.003 and 0.039). Compared with the normal group, the CD3+, CD4+, and CD4+/CD8+ in the 144 patients were lower, while the CD8+ was higher, and the differences were statistically significant (all P<0.05). Before the treatment, there were no statistical differences in T-lymphocyte subsets between the observation group and control group. After the treatment, the CD3+, CD4+, and CD4+/CD8+ in the observation group markedly increased, while CD8+ decreased (all P <0.05). Moreover, the improvement degree of the observation group was much better than that of the control group, with a statisticall difference (P<0.05). Conclusions Lienal polypeptide combined with the CO2 laser in the treatment of condyloma acuminatum has a high efficacy and a low recurrence rate, which may be related to an immune level improvement. Key words: Lienal polypeptide; Ondyloma acuminatum; CO2 laser; Cellular immunity