Effect of lienal polypeptide on immune system in patients with chronic kidney disease (stage CKD5)

Abstract

Objective To study the effect of lienal polypeptide injection on immune function in patients with chronic kidney disease(stage CKD5, uremia). Methods 42 patients with maintenance hemodialysis and 42 patients with peritoneal dialysis in stage CKD5 phase were selected as the research subjects.According to the digital table, they were randomly divided into observation group and control group, 32 cases in each group.All patients were treated with hemodialysis or peritoneal dialysis, the observation group was treated with lienal polypeptide injection, while the control group was treated without lienal polypeptide injection. The immune function index(CD3+, CD4+, CD8+, CD4+/CD8+) were compared between the two groups after treatment for 15 d. Results In the observation group, the immune index after 15 days treatment were CD3+ (58.26±7.90)%, CD4+ (34.46±6.45)%, CD8+ (25.33±4.47)%, CD4+/CD8+ (81.36±0.21). In the control group, the immune index after 15 days treatment were CD3+ (55.64±5.32)%, CD4+ (31.79±7.15)%, CD8+ (27.52±4.68)%, CD4+/CD8+ (1.16±0.18). CD3+, CD4+, CD4+/CD8+ levels of the observation group were significantly higher than those of the control group(t=2.820, t=1.610, t=7.060, all P<0.05). The level of CD8+ was significantly lower than that of the control group(t=0.004, P<0.05). Conclusion Lienal polypeptide can effectively improve the immune function of patients with chronic kidney disease (CKD5 stage). Key words: Lienal polypeptide; Kidney disease; Uremia; Immune function