Abstract
Objective To investigate the effect of thymosin combined with ultra pulsed carbon dioxide (CO2) laser on condyloma acuminatum (CA) and the effect on serum interleukin-2 (IL-2) and interferon-γ (IFN-γ). Methods One hundred and three patients with CA were divided into observation group (n=52) and control group (n=51) according to the treatment regimens. The observation group underwent ultra-pulsed CO2 laser and thymosin treatment, and the control group underwent ultra-pulsed CO2 laser therapy. After 6 months of follow-up, the curative effect and incidence of adverse reactions of two groups were statistically analyzed, and levels of serum IFN-γ and IL-2 between the two groups were compared before and after treatment. Results The total effective rate in observation group [96.15%(50/52)] was significantly higher than that in control group [76.47%(39/51)] (P 0.05; the recurrence rate in observation group [5.77% (3/52)] was lower than that in control group [21.57%(11/51)], the difference was statistically significant (P<0.05). Conclusions Thymosin combined with ultra pulsed CO2 laser in the treatment of condyloma acuminatum (CA) can significantly improve the serum IFN-γ and IL-2 levels, and has low recurrence rate with high safety and more remarkable effect. Key words: Thymosin; Super pulse CO2 laser; Condyloma acuminata; Interleukin-2; Interferon-γ
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