Levodopa combined with entacapone in treatment of Parkinson's disease and its influence on oxidative stress response

Abstract

Objective To investigate the clinical efficacy of levodopa combined with entacapone in the treatment of Parkinson's disease and its influence on oxidative stress response. Methods 94 patients with Parkinson's disease treated at our hospital from April, 2016 to November, 2017 were selected, and divided into a control group and an observation group by randomized controlled method, with 47 cases for each group. The control group were treated with levodopa, while the observation group with levodopa and entacapone. The clinical efficacy, motor function, activity of daily living (ADL), anti-oxidative stress response, and adverse reactions were compared between the two groups. Results The total effective rate was higher in the observation group than in control group (95.74% vs. 74.47%, P 0.05). Conclusions Levodopa combined with entacapone in the treatment of Parkinson's disease is effective and safe, and can improve the motor function, ADL, and anti-oxidative stress response, so it is worth being clinically generalized. Key words: Parkinson's disease; Levodopa; Entacapone; Clinical efficacy; Oxidative stress response