Abstract
Lactobacillus plantarum (L. plantarum) is a well-known probiotic among the ingested-microorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host). However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n = 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 × 108, or 1.03 × 109 colony-forming units/kg/day, designated the vehicle, LP10-1X and LP10-5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight (%). LP10 supplementation dose-dependently increased grip strength (p < 0.0001) and endurance swimming time (p < 0.001) and decreased levels of serum lactate (p < 0.0001), ammonia (p < 0.0001), creatine kinase (p = 0.0118), and glucose (p = 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long-term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health-promotion, performance-improvement, and anti-fatigue effects.
Highlights
The species Lactobacillus plantarum (L. plantarum) is a gram-positive bacterium
We evaluated the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, fatigue-associated biochemical indices, and gastrocnemius muscle fiber profile in mice [21]
We found that six weeks of supplementation with LPS10 significantly improved
Summary
Numerous investigations have revealed that Lactobacillus spp. has various biological effects, such as improving insulin sensitivity, the underlying cause of obesity-associated metabolic abnormalities [1]; inducing cancer cell apoptosis [2]; and antihypertensive [3], cholesterol-lowering [4], anti-inflammation [5], antimicrobial [6], and antioxidation activities [7]. These findings have stimulated an explosion of investigations of Lactobacillus spp., its bioactivities, and its possible role in human health. We further examined a possible mechanism and gut microbiota to explore the mechanism of the probiotic effect on anti-fatigue activity
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call