Anti-Fatigue and Exercise Performance Improvement Effect of Glossogyne tenuifolia Extract in Mice.

Yi-Ju Chen,Marthandam Asokan Shibu,Wan-Teng Lin,Rathinasamy Baskaran

doi:10.3390/nu14051011

Abstract

Glossogyne tenuifolia (GT) is a native perennial plant growing across the coastline areas in Taiwan. The current study aimed to examine the efficacy of GT extract in ameliorating physical fatigue during exercise and increasing exercise performance. Fifty male Institute of Cancer Research (ICR) mice were randomly segregated into five groups (n = 10) to GT extract orally for 4 weeks, at different concentrations (50, 100, 250, and 500 mg/kg BW/day): LGT 1X, MGT 2X, HGT 5X, and HGT 10X groups. Forelimb grip strength, endurance swimming time, serum biochemical marker levels, blood lipid profile and histological analysis of various organs were performed to assess the anti-fatigue effect and exercise performance of GT extract. The forelimb-grips strength and endurance-swimming time of GT-administered mice were increased significantly in a dose-dependent manner when compared to the control. Serum glucose, creatine kinase, and lactate levels were increased significantly in the HGT 10X group. Liver marker serum glutamic-oxaloacetic transaminase (GOT) was increased in the HGT 5X and HGT 10X groups, whereas Serum Glutamic Pyruvic Transaminase (GPT) was not altered. Renal markers, creatinine and uric acid levels, were not altered. Muscle and hepatic glycogen levels, which are essential for energy sources during exercise, were also significantly increased in a dose-dependent manner in all GT extract groups. No visible histological aberrations were observed in the vital organs after GT extract administration. The supplementation with GT extract could have beneficial effects on exercise performance and anti-fatigue function without toxicity at a higher dose.

Highlights

Introduction published maps and institutional affilFatigue is defined as the inability to maintain power output and strength, impairing physical performance
Pharmaceutical Drug Test, Executive Yuan, Kaohsiung, have shown that Lethal dose 50 (LD50 ) of Glossogyne tenuifolia (GT) extract is higher than 10 g/kg BW
G. tenuifolia is a traditional antipyretic and hepatoprotective herb used in Penghu

Summary

Introduction

Introduction published maps and institutional affilFatigue is defined as the inability to maintain power output and strength, impairing physical performance. Insufficient rest, and mental stress/pressure are the causative factors of physiological fatigue, which is further divided into central and peripheral fatigue [1]. Spinal cord, and motor neurons in the central nervous system could result in central fatigue, whereas peripheral fatigue results from muscle weakness induced by changes at the neuromuscular junction [2]. A decline in functional performance could be associated with physiological fatigue [3]. According to the exhaustion theory, a decrease in energy sources, such as glucose, and accumulation of metabolites due to physical performance are causative factors of fatigue [4]. Fatigue is associated with high-intensity exercise-induced exhaustion, suggesting that the functioning muscle capacity has been substantially impaired [5]. The body utilizes key energy sources, such as glucose, hepatic, and iations

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Conclusion