Abstract
This chapter discusses the Kyasanur forest disease (KFD) virus. This virus belongs to the Togaviridae family and causes fever, body ache, hemorrhagic manifestations, and occasionally neurological signs in humans. Fatalities in monkeys are very high. The KFD virus infects man, monkeys, rodents, bats, and small mammals. It has been reported only in India. Other areas are presumed free from it. The KFD virus has been isolated from man and monkeys, ticks, small mammals, and insectivorous bats. This virus grows in ticks but not in mosquito tissue cell culture. Mice immunized with a strain of the Langat virus are reported to withstand challenges from the KFD virus. Haemagglutination inhibition, complement fixation, and virus neutralization are the useful methods for serodiagnosis of the disease. A method called enzyme-linked immunosorbent assay (ELISA) has recently been developed for that purpose. Diagnostic reagents for the KFD virus are available from the National Institute of Virology, Pune, India.
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