Abstract
The therapeutic effectiveness of diazepam in organophosphate intoxication was studied. It was demonstrated that this drug as an adjunct to a mixture of atropine and obidoxime raised the LD50 of fluostigmine in rats to a value about 80 times that in untreated rats. Diazepam alone had no therapeutic effect in these conditions. Diazepam quickly abolished the convulsive electrical activity of the rabbit cortex induced by fluostigmine, normalized the fluostigmine increased amplitude of indirectly elicited twitches of the skeletal muscle of the rat and arrested the disintegration of the muscle action potential observed in these cases. Diazepam had no influence on the block of tetany or on desynchronization of the basal bioelectrical activity of the cortex due to fluostigmine.
Published Version
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