Abstract
In acute and subacute inhalation studies rats were exposed to methylchloroform. In the 4-h exposure the concentrations were approximately 220 and 440 ppm, and in the 3-month study (5×8 h/week) approximately 204 ppm (MAC= 200 ppm). The behavior of methylchloroform and its metabolites (trichloroethanol and trichloroacetic acid) in the expired air, blood, and urine was investigated. A gaschromatographic method for the determination of methylchloroform is described. Most of the methylchloroform is eliminated unchanged via the lungs. In the subchronic inhalation studies, methylchloroform concentrations within the range of the MAC were tolerated with no symptoms. During this time, the concentrations of methylchloroform and trichloroethanol in the blood and the concentration of trichloroacetic acid in the urine remained constant. The urinary trichloroethanol excretion increased until the 10th week, then it fell and remained constant at a level somewhat below the maximum concentration. Methylchloroform was not detectable in organ tissue. The results of the metabolic studies are discussed.
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