Abstract
Pteris quadriaurita, a highly significant underutilized plant species that was widely recognized for its ethnobotanical and ethnomedicinal properties. The work aimed to estimate the flavonoid-rich fraction of P. quadriaurita (PQFRF), which was typically used to alleviate pain, for its antioxidant profile and associated analgesic effectiveness. In-silico molecular docking and PRIME MM-GB/SA studies were performed to analyze the binding pattern of nine bioactive substances identified by gas chromatography-mass spectrometry (GC-MS). The plant’s antioxidant activities were tested in-vitro using DPPH, ferricreducing antioxidant power, Superoxide anion radical, and hydroxy radical scavenging tests. For in-vivo analgesic research, the hot plate model, acetic acid-induced writhing, and tail flicking models were utilised. PQFRF was found to be equipotent to the reference medication in the studied peripheral and central analgesic models at a maximal dose of 50 mg/kg.
Published Version
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