Abstract
One of the most widely spreading diseases due to several lifestyle problems in the 21st century is diabetes mellitus. The management of diabetes mellitus is very important and essential. Plants are natural reservoir of many medicinal value added components help to overcome many chronic disorders including diabetes mellitus. Herbal drugs are prescribed in treatment of diabetes mellitus due to their good effectiveness, fewer side effects in clinical experience and relatively low costs. Screening of antidiabetic therapeutics is very important and essential for effective management of diabetes mellitus. Many researchers have worked on extraction, isolation, characterization of extracts and bioactive fractions from medicinal plant also they have established profile and data of interaction of active components against various targets and enzymes of diabetes mellitus using In-silico molecular docking tools. Molecular docking is an important computational tool to predict the plausible interactions between the drug and protein in a non-covalent fashion. Extensive in silico docking procedures have been carried out to examine whether the compound is a good ligand with diabetic targets. In the present review article we have thoroughly screened research articles published in various scientific, indexed, national and international journals on In-silico molecular docking based screening of Anti-Diabetic potentials and therapeutics from medicinal plant and extensively presented.
Highlights
One of the most widely spreading diseases due to several lifestyle problems in the 21st century is diabetes mellitus (DM)
Extensive in silico docking procedures have been carried out to examine whether the compound is a good ligand with diabetic targets
Many researchers have worked on extraction, isolation, characterization of extracts and bioactive fractions from medicinal plant they have established profile and data of interaction of active components against various targets and enzymes of DM using In-silico molecular docking tools
Summary
One of the most widely spreading diseases due to several lifestyle problems in the 21st century is diabetes mellitus (DM). This disease is generally classified by insulin-dependent or type 1 DM, which is mainly initiated by destruction of the insulin producing pancreatic β-cells, and nondependent insulin or type 2 DM, and this is triggered by lifestyle-related obesity or other exogenous components involve in it. People with type 2 diabetes are not dependent on exogenous insulin and People with type 1 diabetes need to take insulin injection for survival. Oral antidiabetic drugs may be useful for people who are allergic to insulin or do not use insulin injection. Many efforts to develop traditional medicine for the treatment of diabetes are mounting (1)
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