Influence of percutaneous coronary intervention on homocysteine and galection-3 in serum of patients with coronary heart disease and correlation analysis

Abstract

Objective To discuss the influence of percutaneous coronary intervention(PCI) on the serum concentration of homocysteine(Hcy) and galectin-3 in patients with coronary heart disease(CHD). Methods From September 2016 to October 2017, 70 patients in Ji'nan Central Hospital were selected.According to the results of coronary angiography(CAG), they were divided into observation group with drug-eluted stents(n=47, including 25 cases with type A CHD and 22 cases with type B CHD) and control group without abnormal CAG(n=23). Serial venous blood samples were obtained 1 day before PCI as well as 1 day and 7 days after PCI.Plasma concentrations of Hcy, BNP and galectin-3 were measured and compared.The postoperative patients with PCI were tracked for 1 year to observe the influence of serum Hcy and galectin-3 on the severity of CHD and the quality after PCI. Results The plasma Hcy levels of type A[(16.52±5.41)μmol/L]and type B[(19.32±6.35)μmol/L]after PCI were significantly higher than those of the type A[(11.66±3.25)μmol/L]and the type B[(15.87±5.20)μmol/L]before PCI(t=2.375, P<0.05, t=2.97, P<0.01). Meanwhile, the plasma galectin-3 levels of type A[(0.86±0.11)μg/L] and type B[(1.15±0.48)μg/L]after PCI were also higher than those of the type A[(0.32±0.53)μg/L]and the type B[(0.46±0.19)μg/L]before PCI(t=2.178, P<0.05, t=4.269, P<0.01). Furthermore, levels of the plasma Hcy and galectin-3 were positively associated with the severity of CHD. Conclusion The higher blood levels of serum Hcy, BNP and galectin-3 after PCI indicate that the balloon inflation and implantation of stent can affect the level of plasma Hcy, BNP and galectin-3.Therefore, the levels of serum Hcy and galectin-3 are helpful to diagnose CHD and evaluate the degree of CHD. Key words: Coronary artery disease; Percutaneous coronary intervention; Cysteine; Brain natriuretic peptide; Galectin-3; Coronary angiography; Serum; Degree of the lesion