Abstract
ADENO-ASSOCIATED satellite viruses (ASV)1,2, like other members of the parvovirus group, contain single-stranded DNA3. However, satellite viruses are unique in that each capsid contains either a plus or a minus strand of nucleic acid4,5. Although adeno-associated satellite viruses are extreme in their defectiveness and they do not appear to replicate unless viable adenoviruses6,7 or herpes viruses8–10 are present in the system, they do apparently code for their own protein coats which are antigenically distinct from those of the helper adenoviruses11,12. Adeno satellite viruses interfere with the growth of helper adenoviruses13 and also with each other14.
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