Abstract
The adeno-associated satellite viruses were first recognized in 1965. In spite of significant investigations since that time, their role in human disease remains obscure. In an attempt to define this role a longitudinal study of 42 infants (birth–2 yrs.) from a low socioeconomic group was initiated in 1968. The infants were examined at regular intervals and during illnesses. Specimens for viral isolation were collected on each occasion. Sera for antibody titers were obtained at birth and every 3 months thereafter. The purpose of this paper is to report the result of the serologic portion of this study. Neutralization tests revealed that at birth 50% of the infants had antibody to Type 1 satellite virus and 71% to the Type 2-3 complex. These percentages declined to 9% and 18%, respectively, at 6 months, remained low from 6 to 12 months, then rose sharply at 15 months. At 2 years 66% of the infants had antibody against Type 1 and 73% against Type 2-3. Mean geometric titers were high at birth, low from 6–12 months, and highest at 24 months. These data indicate the passive transfer of maternal antibody, and its decline. They also indicate infection due to adeno-associated satellite viruses early in life.
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