Abstract
Telmisartan is an antihypertensive drug which has a low bioavailability value around 42% after a dose of 40 mg and 58% after a dose of 160 mg, this is influenced by the poor level of Telmisartan solubility and directly affects the Telmisartan therapeutic activity. So that Telmisartan research with Gelucire 44/14 was conducted by a solid dispersion method to determine the effect of Gelucire 44/14 usage on increasing dissolution rate of Telmisartan tablets. The study was conducted with 4 Telmisartan tablet formulas by varying the number of Gelucire 44/14 in each formula in the recommended range of use of 15-50%. Formula 1 is a formula with 0% Gelucire 44/14, formula 2 is a formula with 15% Gelucire 44/14, formula 3 is a formula with 30% Gelucire 44/14, formula 4 is a formula with 45% use of Gelucire 44/14. After the mass was printed then dissolution tests were carried out on each formula. From the results of the study, formula 1 produces the average value of dissolution 3,760%, formula 2 produces the average value of dissolution of 22,675%, formula 3 results in an average dissolution value of 34,131%, formula 4 produces an average dissolution value of 45,691%. So it can be concluded that the use of Gelucire 44/14 by the solid dispersion method on the Telmisartan tablet formula has an influence in increasing the dissolution rate of Telmisartan Tablets and formulas that provide the best dissolution rate obtained from formula 4.
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