Abstract
Background: Chronic kidney disease (CKD) is increasingly prevalent among the elderly, leading to progressive kidney function decline and adversely affecting their physical and cognitive well-being. Objective: This study aimed to assess the incidence and effects of renal impairment on physical and cognitive functions in elderly hospitalized patients. Methods: A total of 420 elderly patients admitted with renal impairment to a tertiary care hospital in Karachi were included from January to August 2023. We measured the estimated glomerular filtration rate (e-GFR) and Short Physical Performance Battery (SPPB) score, and collected comprehensive demographic, socioeconomic, and clinical data, including a detailed geriatric assessment. Results: The cohort had a mean age of 78.4±5.8 years, with a nearly even gender split (51.9% male, 48.9% female). Average BMI was 24.8±4.5 Kg/m^2, mean eGFR was 56.6±18.6 mL/min per 1.73 m^2, and mean SPPB score was 4.9±3.5. High prevalence of comorbidities was noted: hypertension (68.6%), diabetes (27.6%), coronary artery disease (28.6%), and others. Renal impairment was categorized as severe (12.9%), mild (27.1%), and moderate (60%). Conclusion: There is a significant correlation between advanced age and renal failure, leading to diminished physical and cognitive capabilities in the elderly, indicating a critical need for integrated care strategies.
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