Abstract
The cytotoxic effect of gold nanoparticles (GNPs) on Rhabdomyosarcoma cells (RMS or RD cell line) has been studied by using Methyl Thiazolyl tetrazolium (MTT) assay. Two sizes of the synthesized GNPs (61nm and 71 nm) functionalized with cetyltrimethylammonium bromide with different concentrations of 3.6 ml of 5 ml CTAB solution were used in the current research. The RD cell line was exposed to these particles for 48 hours. The findings showed that the cytotoxic effects of GNPs appeared to depend on concentration. for both sizes at higher concentration, the inhibition rate of IR absorbance was significantly decreased due to GNPs agglomeration on the cell membrane. Lower concentrations of GNPs internalize the cytoplasmic membrane individually by diffusion. Moreover, average particle diameters of 61nm showed a significant inhibition rate of more than 71nm at a lower concentration.
Published Version
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