Abstract
The immunomodulatory properties of exopolysaccharides (EPS), major components of bacterial biofilm, are not fully understood. Here, we examined the immunomodulatory potential of EPS derived from Bacillus licheniformis BioE-BL11 and Leuconostoc mesenteroides BioE-LMD18, isolated from Korean fermented kimchi. EPS from BioE-BL11 was composed of mannose (12.4%), galactose (1.82%), glucose (48.5%), fucose (37.1%), and arabinose (0.17%), and that from BioE-LMD18 was composed of mannose (8.71%), arabinose (0.07%), galactose (1.22%), glucose (79.8%), and fucose (10.21%). The highest EPS yield were obtained by incubation at 37 °C for 3 days with an initial pH of 7.0, without optimizing other conditions. The EPS from BioE-BL11 and BioE-LMD18 significantly inhibited secretion of the pro-inflammatory cytokine IL-6 in lipopolysaccharide-stimulated RAW264.7 mouse macrophage by 40.7% and 32.1%, respectively, enhanced secretion of the anti-inflammatory cytokine IL-10 in a dose-dependent manner, suggesting that EPS produced by these strains may be useful functional ingredients for the cosmetics, food, and pharmaceuticals industries.
Published Version
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