HYPERURICEMY: EFFECT ON THE CHRONIC HEART FAILURE PATHOGENESIS

Abstract

Purpose - a literature review of the published clinical studies on the effects ofhyperuricemy on the chronic heart failure course(CHF).Conclusions. Studies show that uric acid is associated with cardiovascular disease, and hyperuricemy is common in patients with CHF. Hyperuricemy is associated withimpaired peripheral blood flow and decreased vascular dilatation, which is closelycorrelated with clinical status and reduced physical ability. Recent studies also suggesta close correlation between uric acid levels and myocardial diastolic function and,more importantly, uric acid is determined by a strong, independent prognostic predictorin CHF patients. Current experimental and clinical studies have shown that inhibitionof xanthine oxidase causes significant beneficial pathophysiological changes. Evidenceof this effect suggests that myocardial energy metabolism, endothelial dysfunction,and exercise tolerance are improved at the expense of the decrease of oxidative stressmanifestations, therefore, lowering of the serum levels of the uric acid is a promisingtherapeutic target for improving the treatment of CHF patients.