EFFICIENCY OF DIFFERENT OSTEOPLASTIC MATERIALS USE BEFORE DENTAL IMPLANTATION IN PATIENTS OF RESEARCH GROUPS

Abstract

Objective – to investigate the effectiveness of bone augmentation materials based onmultipotent mesenchymal stromal cells of adipose tissue, which were used to fill bonedefects after various dental surgeries before dental implantation in patients of theresearch groups.Material and methods. Examination and treatment with dental implants were performedon 140 patients who had previously used various osteoplastic materials to increase thebone volume of the alveolar processes of the jaws during surgery. All patients were dividedinto III groups: I (main) group – 49 people (35.0%), in whom the material “Colapan–L”was used to restore the bone tissue of the alveolar processes; ІІ (main) group – 62 patients(44.29%), in whom the augmentation of bone defects was carried out with the help ofour proposed composition (“Colapan–L”+MMSC–ATT +PRP); Group III (control) – 29patients (20.71%) in whom wound healing occurred under a blood clot (spontaneous).Statistical processing of the results was performed on a personal computer using licensedprograms "Microsoft Excel" and "Statistica".Results. It was found that in patients, in whom a combination based on multipotentmesenchymal stromal cells of adipose tissue, the drug “Colapan-L” and platelet-richplasma was used to fill bone defects, peri-implant tissues were completely restored afterinsertion of dental implants. Also, the adequacy of our proposed osteoplastic compositionwas confirmed by X-ray examination: after 12 months of studies in patients of the maingroup II, the values of bone resorption in the implantation sites were 1.4 times and 1.8times lower than in patients of the main group, p1<0.01, and control group III, p2<0.01,respectively.Conclusions. The effectiveness of osteoplastic materials based on multipotentmesenchymal stromal cells of adipose tissue was confirmed by the values of the stabilitycoefficient of implants, which after 12 months of the research were probably higher thanthe reference, p<0.01, and 12.43% and 19.33% higher than in patients of the I main andIII control groups.