EFFICIENCY OF THE COMBINATION BASED ON BONE AUGMENTATION MATERIALS AND MULTIPOTENT MESENCHYMAL STROMAL CELLS OF ADIPOSE TISSUE IN PATIENTS OF STUDY GROUPS BEFORE DENTAL IMPLANTATION

Abstract

In recent decades, the most common method of treating partial or complete adentia is the use of dental implants. Often, due to insufficient jaw bone volume due to atrophy in the are of the removed teeth, it is impossible to perform intraosseous implantation. In order to eliminate the defi cit of bone tissue before the installation of dental implants, surgical interventions are required. Examination and treatment with dental implants were performed on 140 patients who had previously undergone surgery and used bone augmentation materials and their combinations with multipotent mesenchymal stromal cells of adipose tissue to increase the volume of jaw bone tissue. 3 months after the installation of dental implants in patients of group I, in which the restoration of the volume of bone tissue of the jaws was performed using bone augmentation material «Colapan–L», and in persons of group II, where augmentation was used a combination of drug «Colapan–L», multipotent mesenchymal stromal cells of adipose tissue and platelet-rich plasma, the values of the OHI–S index corresponded to the data before treatment, p>0.05, and were equal to each other, p2>0.05. In the control group III, the values of this index increased 1.4 times relative to baseline, p <0.05, and were signifi cantly higher than in patients of groups I and II, p1<0.01. After 3 months of observation, a decrease in the PMA index data relative to baseline values was determined: 1.2 times in group I, p, p1 <0.01, and 1.1 times in group II, p <0.05, p1, p2<0,01. At the same time, in patients of group III the values of this parameter increased and were 1.3 times higher than the reference values, p <0.01. After 6 months of studies in patients of groups I and III, the values of the SchillerPisarev test were higher than the initial data, p<0.05, and were equal to each other, p1>0.05. In patients of group II, the values of this parameter were equal to the initial data, p>0.05, and were probably lower data in persons of groups I and III, p1, p2<0.01. It was found that in patients in whom a combination based on multipotent mesenchymal stromal cells of adipose tissue, the drug «Colapan–L» and platelet- enriched blood plasma was used to fi ll bone defects, peri-implant tissues were completely restored after dental implants. The effectiveness of our proposed osteoplastic combination in patients of the study groups was confi rmed by the positive dynamics of the values of the hygienic index OHI-S, periodontal index PMA and Schiller- Pisarev test during the observation.