EXPERIENCE IN APPLYING OSTEOPLASTIC MATERIALS CONTAINING MULTIPOTENT MESENCHYMAL STROMAL CELLS AND HYDROXYAPATITE IN PATIENTS BEFORE THE PROCEDURE OF DENTAL IMPLANT PLACEMENT

Abstract

Introduction of modern osteoplastic material into practical work is extremely important for effective filling of bone defects, restoration of lost periodontal tissue, relief of postoperative symptoms and reduction of inpatient treatment of patients after surgery. Up-to-date materials will improve regenerative and reparative properties of the bone tissue and promote its increasing volume for further successful dental implantation. Objective of the research was to determine an application effect of osteoplastic materials based on multipotent mesenchymal stromal cells of the adipose tissue and hydroxyapatite used for filling bone defects during dental surgery in patients, before dental implantation. Materials and methods. 140 patients were examined and treated by means of dental implantation. Before implantation, in order to increase the volume of the bone tissue of the cellular processes and cellular part of the corresponding jaw, various osteoplastic materials were applied during surgery. All the patients were distributed into III groups: І included 49 individuals (35,0 %), II group – 62 patients (44,29 %), and III (control) group included 29 patients (20,71 %). In I group a bone tissue substitute based on hydroxyapatite was used to restore the bone tissue of the cellular processes and the cellular pert of the corresponding jaw. In II group augmentation of bone defects was carried out by means of the suggested composition consisting of multipotent mesenchymal stromal cells of the adipose tissue, platelet-rich blood plasma and bone tissue substitute based on hydroxyapatite. In ІІІ group, the wound healed spontaneously under a blood clot. Results. After installation of dental implants, the peri-implant tissues were found to restore completely in cases where the combination of multipotent mesenchymal stromal cells of the adipose tissue, a bone substitute based on hydroxyapatite, and platelet-rich blood plasma was used for filling bone defects. Moreover, according to X-ray findings obtained 12 months later, in patients from II group the volume of the bone tissue resorption in the areas of implantation was 1,4 and 1,8 times lower than in individuals from І group, р1<0,01, and ІІІ control group, р2<0,01, respectively. Conclusions. The effectiveness of application of osteoplastic materials based on multipotent mesenchymal stromal cells of the adipose tissue and hydroxyapatite is confirmed by the values of the stability coefficient of implants. After 12 months of the research, these values were reliably higher than those of the reference, р<0,01. They were 12,43 % and 19,33 % higher than in patients from І main group and ІІІ control group.