Abstract
HTRT consists of daily hyperthermia treatments in conjunction with each radiation fraction. Radiation daily doses are progressively decreased from 180 to 100 cGy resulting in protracted treatment time that decreases the isoeffect biological equivalent dose by 15% to 25%. This decrease is compensated by the increased number of hyperthermia fractions which potentiates each radiation dose. Treatment is continued until an objective complete response is attained, or failure determined. Sixty breast patients, 35 head and neck, and 25 prostate patients were treated with a followup of two to five years. All patients were early stage (less than III). HTRT proved to be less toxic and more effective than radiation or chemoradiation therapies.
Highlights
Hyperthermia, applied regionally, is a potent sensitizer of radiation therapy in the treatment of cancerous tumors [1,2,3,4,5,6,7,8,9,10] and as such has been used as a palliation measure [11,12,13] or more recently with curative intent [14]
We report on an expanded series of patients as well as performing a metaanalysis comparing Hyperfractionated Thermoradiotherapy (HTRT) with external beam radiation (EBRT) or chemoradiation
Thermometry was done using microthermocouples placed in the tumor region (BCIW, LA, and CA); for prostate tumors only ultrasound was used
Summary
Hyperthermia, applied regionally, is a potent sensitizer of radiation therapy in the treatment of cancerous tumors [1,2,3,4,5,6,7,8,9,10] and as such has been used as a palliation measure [11,12,13] or more recently with curative intent [14]. The ability of Hyperthermia to reoxygenate tumor tissue makes hypoxic tumors, such as sarcomas or glioblastomas, more responsive to radiation [15]. We report on an expanded series of patients as well as performing a metaanalysis comparing HTRT with external beam radiation (EBRT) or chemoradiation
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