Abstract
Small-cell lung cancer (SCLC) is one of the most aggressive and lethal forms of lung cancers. Chemotherapy and radiotherapy would be standard modality for SCLC with median survival being less than 4 months only. Complementary treatment to chemotherapy is desired. Oncothermia will be one of the candidates to this addition. We have made a study of 31 SCLC patients from April 2006 to March 2012. 23 cases were treated with combined chemotherapy and oncothermia, and 8 cases were treated with chemotherapy alone. Three patients from 14 patients (14/31) died in the study period; there were equal numbers in the two arms, including one long survival case of 28 months and one of 26 months, in the combination and chemo-group, respectively .16 patients (16/31) are alive: 4 patients with chemotherapy only, including one long survival case of 28.7 months, and 11 cases with combined therapy including three long survival cases of more than 3 years. We conclude that the combined use of chemotherapy and oncothermia has significantly enhanced the survival rate in comparison with the use of chemotherapy alone (log-rank test: P value < 0.02).
Highlights
Introduction and BackgroundLung cancer is one of the most common causes of cancerrelated deaths in both men and women worldwide
The logrank test to compare survival distributions between the two groups had hazard ratio and 95% confidence interval using Cox proportional hazard regression showing P = 0.02
(2) Small cell lung cancer can primarily be covered by chemotherapy, but tolerance against the anticancer agent is created frequently, and the return of disease or metastasis takes place very often, which indicates a poor prognosis
Summary
Lung cancer is one of the most common causes of cancerrelated deaths in both men and women worldwide. Chemotherapy and radiation therapy were performed on the tumor after complete resection, and the relationship does not cause death in 19 patients with autopsy, in 13 patients small-cell lung cancer metastases have been cured [10]. In consequence the surrounding blood vessels expand, the blood flow increases and delivers extra nutrition for tumor accelerating its stable proliferation In this case, the temperature rise of the cancerous tissue will have more metabolic and proliferation activity. By these actions the cell membrane is destroyed and will destroy the cancerous tissue [39] For these reasons we expect the effect on the disseminated SCLC lesions with combination of chemotherapy and radiation therapy. Our present study tries to provide more details in this important field of oncology
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