Abstract
Background. Modulated electrohyperthermia (mEHT) is a noninvasive technique for targeted tumor treatment. Method. HT29 human colorectal carcinoma cell line xenografted to both femoral regions of BalbC/nu/nu mice was treated with a single shot OTM treatment. Histomorphologic, immunohistochemical analysis TUNEL assay, and R&D Apoptosis array were performed on tissue samples. Results. mEHT caused a selective tumor demolition. An upregulation of TRAIL-R2 and FAS was observed. Cleaved caspase-3 positive cells appear at the tumor periphery. Cytochrome c and AIF release was observed in line with massive TUNEL positivity. Conclusion. In HT29 colorectal cancer xenograft, mEHT caused massive caspase independent cell death.
Highlights
Modulated electrohyperthermia is a noninvasive technique for targeted tumor treatment
Already it was shown that Modulated electrohyperthermia (mEHT) has nontemperature dependent effect beside the temperature dependent one [8]
Our aim was to detect the possible role of mEHT in tumor cell death
Summary
Modulated electrohyperthermia (mEHT) is a noninvasive technique for targeted tumor treatment. HT29 human colorectal carcinoma cell line xenografted to both femoral regions of BalbC/nu/nu mice was treated with a single shot OTM treatment. Cleaved caspase-3 positive cells appear at the tumor periphery. Cytochrome c and AIF release was observed in line with massive TUNEL positivity. In HT29 colorectal cancer xenograft, mEHT caused massive caspase independent cell death. Modulated electrohyperthermia (mEHT) is a noninvasive technique for targeted tumor treatment [1,2,3,4]. Our aim was to detect the possible role of mEHT in tumor cell death
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