Abstract

Hansen solubility parameters (HSP) have been successfully used as a real decision-making tool for the crucial step of solvent selection in many technological applications. One of these applications is the extraction of bioactive compounds from natural sources. This chapter devotes to the use of HSP for selection of green extraction solvents, including a brief description about bio-based solvents, supercritical carbon dioxide, ionic liquids and natural deep eutectic solvents. In addition, the HSP theoretical approach for the estimation of natural compounds in some of the above mentioned solvents is included. A case study for the prediction of green solvent extraction of a carotenoid (fucoxanthin) from microalgae, employing the software HSPIP® is discussed. Finally, an updated discussion of the most recent applications of HSP on green extraction and some concluding remarks about the importance of using this solvent selection approach in the near future are included.

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