Abstract
Nanoparticle systems are highly fascinating because of their unique physicochemical properties. Gold nanoparticles (Au NPs) can be applied in medical applications due to its biocompatibility and chemical nontoxicity. In this work, gold-embedded gum ghatti-grafted polyacrylamide (Gg-g-AM(Au)) nanocomposite was synthesized via an in situ polymerization method. The synthesized Gg-g-AM(Au) nanocomposite was characterized by using various techniques such as UV–visible spectroscopy, FTIR, XRD and FESEM. The Gg-g-AM(Au) nanocomposite was used for in vitro release of curcumin at pH 1.2 and 7.4. To evaluate drug release mechanisms and kinetics, the release data were fitted to zero order, first order, Korsmeyer-Peppas, and Higuchi models. The antibacterial behavior of the nanocomposite systems was also investigated. The Gg-g-AM(Au) nanocomposite systems can be considered as a good carrier towards in vitro release of the curcumin.
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