Formulation, Evaluation and Release Kinetics of Low Viscosity Metronidazole Gel with Varying Amount o f Carbopol

Abstract

Objective: The study is centered on formulation and evaluation of low viscosity metronidazole gel with varying amount of Carbopol. Methods: Formulations (F1, F2 and F3) of Metronidazole in gel form were done in varying amounts of Carbopol. Prepared gels were inspected for surface pH, viscosity, spreadability, antimicrobial susceptibility, drug content percentage, in vitro process of drug release, release kinetics and stability testing. Findings: Formulation pH was placed in between 5 and 6. Measured viscosity of F3 was 34.16 Pa.sec for high-rise amount of Carbopol and for F2 & F1 it was 33.43 Pa.sec and 30.44 Pa.sec respectively. Highest spreadability was achieved for F1 which was 9.72 gm.cm/sec and for F2 and F3 it was 7.3 gm.cm/sec & 6.62 gm.cm/sec. Release study for drug (In vitro) report for F1, F2, and F3 was 91.945 %, 89.612 % and 88.598 % respectively for 120 minutes study. Drug release kinetics was scrutinized by First Order model, Zero Order model, Higuchi model, Hixon- Crowell model and Korsmeyers-Peppas model. Novelty: This study formulates low viscosity gel of metronidazole using polymer Carbopol. The viscosity of gel formulation can alter drug release pattern and spreadability in better way. Study was focused on improvement of spreadability which is linked with easy absorption in to the application area. Low viscosity aqueous gel can spread easily. Keywords: Periodontal Disease; Metronidazole; Carbopol; In Vitro Type Drug Release; Kinetics For Drug Release