Abstract
Curcumin and curcumin-β-cyclodextrin (CD) inclusion complex were successfully encapsulated in almond gum/polyvinyl alcohol (PVA) nanofibers using electrospinning procedure. The release mechanisms and kinetics of encapsulated curcumin and curcumin-βCD inclusion complex were evaluated in simulated gastrointestinal and simulated saliva conditions. The release data were fitted to zero order, Kopcha, Korsmeyer-Peppas, and Higuchi models to evaluate release mechanisms and kinetics. The controlled release of curcumin in simulated gastrointestinal and simulated saliva conditions showed that the nanofibers containing complex had the higher release in comparison of only curcumin at all time points. This can be related to the higher solubility of curcumin incorporated into the βCD. The release profile of curcumin and its complex were similar. Release kinetics of curcumin and its complex in both simulated gastrointestinal and simulated saliva conditions followed a Fickian diffusion mechanism. The release data were well fitted with Kopcha, Korsmeyer-Peppas, and Higuchi models with R2 values higher than 0.9176.
Highlights
Curcumin is a natural colorant which is obtained from the rhizome of the herb Curcuma longa
It was observed that by increasing the amount of curcumin complex in nanofibers loading efficiency slightly increased. These results indicated that almost 100% of complexed curcumin was protected after being incorporated into almond gum/Polyvinyl alcohol (PVA) nanofibers
Almond gum/PVA nanofibers containing curcumin and curcumin-β-cyclodextrin inclusion complex were successfully prepared by electrospinning process
Summary
Curcumin is a natural colorant which is obtained from the rhizome of the herb Curcuma longa. Curcumin is a hydrophobic polyphenol and has many food and pharmaceutical applications. Curcumin can be used as a natural colorant and as a stabilizer in jellies. It can be used as an artificial colorant replacer in cheeses, yogurts, The application of curcumin is restricted in the food industry and pharmaceutical formulation due to its poor solubility and low stability in different conditions. Curcumin has high sensitivity to light, thermal treatment, alkaline conditions, oxygen, enzyme, metallic ions and ascorbic acid [6]. To overcome these limitations, encapsulation is a suitable technique. Among three CDs, βCD can better fit with different molecules with molecular weights between 200 and 800 g/mol
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