Abstract
In this study, experimental data on the biological action of glyproline peptides — Pro-Gly-Pro, Pro-ArgPro, Arg-Pro-Gly-Pro and Pro-Gly-Pro-Leu — on the processes of blood coagulation and lipid metabolism were obtained using animal models of metabolic syndrome. Under the conditions of increased blood clotting and hypercholesterolemia, the regulatory peptides under study were administered intranasally for 7 days once every 24 hours. 20 hours after the last peptide administration, thromboelastogram parameters confi rmed the restoration of the functional state of the coagulating and anticoagulant systems. In addition, a simultaneous positive shift in the parameters of lipid metabolism was observed. These changes lasted for 7 days following the withdrawal of the drugs. It is found that the biological action of the peptides under study consists in their simultaneous regulatory impact on the processes of hemostasis and lipid metabolism.
Highlights
In this study, experimental data on the biological action of glyproline peptides — Pro-Gly-Pro, Pro-ArgPro, Arg-Pro-Gly-Pro and Pro-Gly-Pro-Leu — on the processes of blood coagulation and lipid metabolism were obtained using animal models of metabolic syndrome
It is found that the biological action of the peptides under study consists in their simultaneous regulatory impact on the processes of hemostasis and lipid metabolism
Результаты и их обсуждение На модели крыс с метаболического синдрома (МС), который вызывали 6-недельным кормлением пищей, обогащенной жирами и углеводами, при постоянном соблюдении крысами высококалорийной диетой (ВКД) были продемонстрированы гемостазиологические эффекты регуляторных пептидов с одновременным их влиянием на жировой обмен
Summary
Experimental data on the biological action of glyproline peptides — Pro-Gly-Pro, Pro-ArgPro, Arg-Pro-Gly-Pro and Pro-Gly-Pro-Leu — on the processes of blood coagulation and lipid metabolism were obtained using animal models of metabolic syndrome. Результаты и их обсуждение На модели крыс с МС, который вызывали 6-недельным кормлением пищей, обогащенной жирами и углеводами, при постоянном соблюдении крысами ВКД были продемонстрированы гемостазиологические эффекты (по данным тромбоэластографического исследования крови) регуляторных пептидов с одновременным их влиянием на жировой обмен. В течение 7-ми раз, применения каждого из пептидов было установлено, что спустя 20 ч у крыс на фоне ВКД в плазме крови снижался уровень ОХ на 8–10%, Хс-ЛПНП — на 8% (PGP), 17% (PRP), 24% (PGPL), 31% (RPGP) и триглицеридов — на 40% (PRP), 44% (PGPL), 49% (PGP), 48% (RPGP).
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