Rasprostranennost' narusheniy svertyvayushchey i protivosvertyvayushchey sistem krovi u zhenshchin s metabolicheskim sindromom v postmenopauze

Abstract

The object of the study was to assess the prevalence of prothrombotic alterations in coagulant and anticoagulant systems among postmenopausal women with metabolic syndrome and to determine the associations between these abnormalities and main anthropometric measures and parameters of glucose and lipid metabolism. Cross-sectional observational study included 55 postmenopausal women (age 45-65) with metabolic syndrome. Coagulant system was assessed by measurement of parameters of plasma haemostasis (prothrombin index, Activated Partial Thromboplastin Time (APTT), thrombin time, fibrinogen concentration), and the activities of coagulant factors VII (FVII) and VIII (FVIII) in plasma. In order to investigate the functioning of anticoagulant system the activities of antithrombin III and anticoagulant system of protein C were measured. Prothrombotic alterations were observed in 81,5% women. The APTT was decreased in 14,5%, hyperfibrinogenemia was revealed in 42,6%, the increased activity of FVII - in 50,9%, and the decreased activity of protein C system - in 23,9%. There were a significant positive associations between some of revealed prothrombotic alterations and anthropometric and biochemical markers of visceral obesity and metabolic syndrome (parameters of glucose and lipid metabolism). There were no any associations between haemostatic indices and age. In conclusion, there is an evidence of high prevalence of different prothrombotic alterations in coagulant and anticoagulant systems among postmenopausal women with metabolic syndrome. Metabolic syndrome in postmenopause is associated with the development of prothrombotic state independently of age.